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KMID : 0043320100330010167
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Archives of Pharmacal Research
2010 Volume.33 No. 1 p.167 ~ p.173
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The Proanthocyanidins Inhibit Dimethylnitrosamine-induced Liver Damage in Rats
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Moon Jeon-Ok
Yoon Sik
Shin Mi-Ok
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Abstract
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Proanthocyanidins are naturally occurring compounds widely available in fruits, vegetables, nuts and seeds. They are a class of phenolic compounds and have been reported to exhibit a wide range of biological effects. In this study, we investigated the protective effect of grape seed proanthocyanidins on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant increase in levels of serum alanine transaminase, aspartate transaminase, alkaline phosphatase, and bilirubin. Oral administration of proanthocyanidins (20 mg/kg daily for 4 weeks) remarkably prevented these elevations. Proanthocyanidins also restored serum albumin and total protein levels, and reduced the hepatic level of malondialdehyde. Furthermore, DMN-induced collagen accumulation, as estimated by histological analysis of liver tissue stained with Sirius red, was reduced in the proanthocyanidinstreated rats. A reduction in hepatic stellate cell activation, as assessed by α-smooth muscle actin staining, was associated with proanthocyanidins treatment. In conclusion, these results demonstrate that proanthocyanidins exhibited in vivo hepatoprotective and anti-fibrogenic effects against DMN-induced liver injury. It suggests that grape seed proanthocyanidins may be useful in preventing the development of hepatic fibrosis.
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KEYWORD
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Proanthocyanidins, Grape seed, Hepatoprotective effect, Anti-fibrogenic effect, Liver fibrosis, Hepatic stellate cell
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